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Decreased incidence of indomethacin-induced gastric ulceration in rats by bile duct diversion

✍ Scribed by Foroogh S. Abtahi; Bijan Djahanguiri

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 197 KB
Volume: 62
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800620208

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✦ Synopsis

Abstract

Gastric mucosal ulceration was produced in rats following intraperitoneal injection of indomethacin (40 mg/kg). The incidence of ulcerations was progressively reduced as the bile flow was diverted progressively distal to the ampulla of Vater. It is suggested that bile reflux into the stomach may play a part in the pathogenesis of indomethacin-induced gastric ulceration in rats.

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