Effects of S-Adenosyl- L -methionine and interferon-α2b on liver damage induced by bile duct ligation in rats
✍ Scribed by Pablo Muriel; Virginia Castro
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 76 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
Interferon-␣ 2b (IFN) is known to prevent and to reverse experimental liver fibrosis and damage. S-Adenosyl-l-methionine (SAM) is a well-known hepatoprotective substance. The aim of the present work was to determine the effect of the administration of both drugs simultaneously to bile duct-ligated rats. Administration of IFN (50 000 IU s.c.) and/or SAM (10 mg kg -1 i.m.) began 15 days after biliary obstruction and continued for a further 15 days. The liver was used for glycogen and collagen quantification. Bilirubins and enzyme activities were measured in serum. Either SAM or IFN ameliorated all markers of liver damage studied. However, when administered together their beneficial effects were markedly reduced. It is not possible to explain the antagonistic effect of these compounds on liver damage with the present data. More studies are needed to determine SAM-IFN interactions.