B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are involved in normal B cell survival and differentiation. We analyzed BAFF and APRIL plasma levels in patients with B-cell chronic lymphocytic leukemia (B-CLL). We also tested intracellular BAFF and APRIL expression in B-C
Role of BAFF and APRIL in human B-cell chronic lymphocytic leukaemia
✍ Scribed by Stéphanie Haiat; Christian Billard; Claire Quiney; Florence Ajchenbaum-Cymbalista; Jean-Pierre Kolb
- Book ID
- 108781883
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 306 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0019-2805
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Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B-CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18