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Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease

✍ Scribed by David H. Small; Lisa R. Fodero; Dusan Losic; Cindy Chu; Marie-Isabel Aguilar; Lisandra L. Martin; Mary Chebib

Book ID
112751885
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
484 KB
Volume
10
Category
Article
ISSN
1573-3149

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## Abstract Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of dementia in the elderly associated with cholinergic dysfunction, including reductions in nicotinic acetylcholine receptors (nAChRs). In AD, astrocytes are implicated in the formation of senile plaques, one