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Genetic Variation in the α7 Nicotinic Acetylcholine Receptor is Associated with Delusional Symptoms in Alzheimer’s Disease

✍ Scribed by Robyn Carson; David Craig; Dominic Hart; Stephen Todd; Bernadette McGuinness; Janet A. Johnston; Francis A. O’Neill; Craig W. Ritchie; A. Peter Passmore

Book ID
107568595
Publisher
Humana Press Inc
Year
2008
Tongue
English
Weight
301 KB
Volume
10
Category
Article
ISSN
1535-1084

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Alzheimer's disease is associated with a
Alzheimer's disease is associated with a selective increase in α7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
✍ Thanasak Teaktong; Alison Graham; Jennifer Court; Robert Perry; Evelyn Jaros; Ma 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB

## Abstract Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of dementia in the elderly associated with cholinergic dysfunction, including reductions in nicotinic acetylcholine receptors (nAChRs). In AD, astrocytes are implicated in the formation of senile plaques, one