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Role of astrocytic nucleoside transporters on oxidative stress

✍ Scribed by Koh-ichi Tanaka; Nobue Kitanaka; Junichi Kitanaka; Tomoaki Sato; Takashige Nishikawa; Motohiko Takemura; Nobuyoshi Nishiyama

Book ID: 116777560
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 99 KB
Volume: 68
Category: Article
ISSN: 0168-0102
DOI: 10.1016/j.neures.2010.07.2131

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## Abstract In amyotrophic lateral sclerosis (ALS) non‐neuronal cells play key roles in disease etiology and loss of motoneurons via noncell‐autonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for L‐glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS