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Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

✍ Scribed by Jae-Hyuk Yi; Alan S. Hazell

Book ID
116764769
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
642 KB
Volume
48
Category
Article
ISSN
0197-0186

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## Abstract In amyotrophic lateral sclerosis (ALS) non‐neuronal cells play key roles in disease etiology and loss of motoneurons via noncell‐autonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for L‐glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS