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Role of APOE in Alzheimer's disease-like neurodegeneration

✍ Scribed by David M. Holtzman; Anne M. Fagan; Kelly R. Bales; Ronald DeMattos; Michael C. Irizarry; Karen H. Ashe; Bradley T. Hyman; Steven M. Paul

Book ID: 117411573
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 396 KB
Volume: 21
Category: Article
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(00)82422-7

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## Abstract Accumulating evidence has indicated that gain‐of‐function in β‐amyloid production may be not the necessary mechanism for mutant presenilin‐1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in