Role of an intronic polymorphism in thePDCD1gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies
โ Scribed by Dharambir K. Sanghera; Susan Manzi; Franklin Bontempo; Cara Nestlerode; M. Ilyas Kamboh
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 101 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0340-6717
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## Abstract ## Objective The R620W (1858CโT) polymorphism in __PTPN2__2 has been implicated in type 1 diabetes mellitus, rheumatoid arthritis, Graves' disease, Hashimoto thyroiditis, autoimmune thyroid disease, and systemic lupus erythematosus (SLE). The aim of this study was to evaluate this poly
Familial associations of the antiphospholipid antibody syndrome (APS) offer the opportunity to study genetic mechanisms of autoantibody production and disease, but are unusual. We identified a family, including identical twins and their mother, in which all members had systemic lupus erythematosus (