Different manifestations of the antiphospholipid antibody syndrome in a family with systemic lupus erythematosus

✍ Scribed by Kimberly P. May; Sterling G. West; Joann Moulds; Brian L. Kotzin

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 524 KB
• Volume: 36
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780360413

✦ Synopsis

Familial associations of the antiphospholipid antibody syndrome (APS) offer the opportunity to study genetic mechanisms of autoantibody production and disease, but are unusual. We identified a family, including identical twins and their mother, in which all members had systemic lupus erythematosus (SLE) and presented with different manifestations of the APS.

Methods. Review of case histories and clinical laboratory results, antiphospholipid antibody (aPL) studies, complement C4 protein and gene analysis, and HLA typing of family members were performed.

Results. Each of the 3 family members presented with a different clinical association of the APS. These

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The opinions and assertions contained herein are those of the authors and do not necessarily represent those of the United States Department of the Army, Department of the Air Force, or