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Role of Active Site Tyrosine Residues in Catalysis by Human Glutathione Reductase †

✍ Scribed by Krauth-Siegel, R. Luise; Arscott, L. David; Schönleben-Janas, Annette; Schirmer, R. Heiner; Williams, Charles H.

Book ID: 127133481
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 325 KB
Volume: 37
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi980637j

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Understanding the role of active-site residues in enzymatic catalysis is of fundamental importance for a microscopic description of the catalytic mechanism, but also for the design of effective enzyme mimics or improvement of existing enzymes (or abzymes) for catalyzing chemical reactions. Site-dire