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Role of acetylcholinesterase in airway epithelium-mediated inhibition of acetylcholine-induced contraction of guinea-pig isolated trachea

✍ Scribed by Koga Yoshihisa; Satoh Shun; Sodeyama Naoya; Hashimoto Yasuhiko; Yanagisawa Teruyuki; Carol A. Hirshman


Book ID
115888046
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
855 KB
Volume
220
Category
Article
ISSN
0014-2999

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro