Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4 ΓΎ T cells, including Th3 cells, T R cells, CD4 ΓΎ CD25 ΓΎ cells and NKT cell
Role and modulation of T-cell cytokines in allergy
β Scribed by Angelika Daser; Nicole Meissner; Udo Herz; Harald Renz
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 1000 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0952-7915
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β¦ Synopsis
Allergic sensitization and the development of effector functions are controlled by IL-4-secreting and IL-5-secreting type 2 T cells. Recent studies have provided new insights into the events triggering the development of type 1 and type 2 T cells, the discrimination of type 1 and type 2 effector T cells from various T-cell subsets, and the improvement of established and new therapeutic strategies, which are aimed at modulating such T-cell functions in the allergic patient.
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