Robustness of viral clearance
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 43 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0006-3592
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Viral clearance across ceramic hydroxyapatite (CHT TM ) was examined in two elution systems: sodium chloride and sodium chloride plus poly(ethylene glycol) (PEG). In both cases clearance of xenotropic murine leukemia virus was significant (3-4 log) while that of minute virus of mice varied between 1
## Abstract Strong anion exchange chromatography has frequently been employed as a viral clearance step during downstream processing of biological therapeutics. When challenged with viruses having only slightly acidic isoelectric points, the performance of the anion exchange operation becomes highl