✦ LIBER ✦

Robust methods for the detection of genetic linkage for quantitative data from pedigrees

✍ Scribed by C. I. Amos; Dr. R. C. Elston; D. C. Rao

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 676 KB
Volume: 6
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370060205

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Power and robustness of linkage tests fo

Power and robustness of linkage tests for quantitative traits in general pedigrees

✍ Wei-Min Chen; Karl W. Broman; Kung-Yee Liang 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB 👁 2 views

There are numerous statistical methods for quantitative trait linkage analysis in human studies. An ideal such method would have high power to detect genetic loci contributing to the trait, would be robust to non-normality in the phenotype distribution, would be appropriate for general pedigrees, wo

Improved programs for the affected-pedig

Improved programs for the affected-pedigree-member method of linkage analysis

✍ Mark Schroeder; Deborah L. Brown; Daniel E. Weeks 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB

The affected-pedigree-member (APM) method is a non-parametric method of linkage analysis, which requires no assumptions about how the trait of interest is inherited [Weeks and Lange, 1988, 1991, 1992; Lange and Weeks, 1990; Weeks et al., 1992]. The APM method uses only the affected members of each p

PEL: an unbiased method for estimating a

PEL: an unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history

✍ F. Alarcon; C. Bourgain; M. Gauthier-Villars; V. Planté-Bordeneuve; D. Stoppa-Ly 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

## Abstract Providing valid risk estimates of a genetic disease with variable age of onset is a major challenge for prevention strategies. When data are obtained from pedigrees ascertained through affected individuals, an adjustment for ascertainment bias is necessary. This article focuses on ascer

Method for the quantitative evaluation o

Method for the quantitative evaluation of data from flow microfluorometry

✍ Jerrold Fried 📂 Article 📅 1976 🏛 Elsevier Science 🌐 English ⚖ 803 KB

A new method is proposed for estimating the distribution of cells among the phases of the mitotic cycle using data from a flow microfluorometer. The method can be applied to asynchronous or synchronous cell populations, and is not limited to systems with very low coefficients of variation of fluores

Statistical properties of a variance com

Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees

✍ Jeff T. Williams; Ravindranath Duggirala; John Blangero 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 54 KB 👁 2 views

We investigated the statistical properties of a variance components method for quantitative trait linkage analysis using nuclear families and extended pedigrees.

Maximum-likelihood-binomial method for g

Maximum-likelihood-binomial method for genetic model-free linkage analysis of quantitative traits in sibships

✍ Alexandre Alcaïs; Laurent Abel 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 3 views

Sib-pair linkage studies are widely used to investigate the genetic factors implicated in complex quantitative traits. To analyze these data, we propose a Maximum-Likelihood-Binomial (MLB) approach, which considers the sibship as a whole and relies on the idea of binomial distributions of parental a