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Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2

โœ Scribed by J. N. KING; J. P. ARNAUD; E. I. GOLDENTHAL; P. GRUET; M. JUNG; W. SEEWALD; P. LEES


Book ID
108885532
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
326 KB
Volume
34
Category
Article
ISSN
0140-7783

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To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. As markers