RNA Trafficking and Nuclear Structure Dynamics

✍ Scribed by Melpomeni Platani, Angus I. Lamond (auth.), Professor Dr. Philippe Jeanteur (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2008
Tongue: English
Leaves: 161
Series: Progress in Molecular and Subcellular Biology 35
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Over the last few years remarkable progress has been accomplished with respect to our understanding of nuclear structure and trafficking. This volume concentrates on aspects that involve or are of relevance to RNA and RNPs. Topics include fundamental advances and current problems in the structural organization of different subnuclear compartments: chromatin, nucleolus and perinucleolar compartment, Cajal bodies and gems, speckles containing splicing factors, as well as the PML bodies characteristic of ProMyelocytic Leukemia. It also describes recent progress in the dynamic aspects of RNA trafficking and in the latest technologies for live cell imaging of mRNA. The major general message of this volume is that nuclear structure is much more dynamic than previously anticipated.

✦ Table of Contents

Front Matter....Pages I-IX
Nuclear Organisation and Subnuclear Bodies....Pages 1-22
Searching for Active Ribosomal Genes....Pages 23-56
Toxic RNA in the Nucleus: Unstable Microsatellite Expression in Neuromuscular Disease....Pages 57-77
Assembly and Traffic of Small Nuclear RNPs....Pages 79-97
Intranuclear Pre-mRNA Trafficking in an Insect Model System....Pages 99-118
Photobleaching Microscopy Reveals the Dynamics of mRNA-Binding Proteins Inside Live Cell Nuclei....Pages 119-134
Imaging of Single mRNAs in the Cytoplasm of Living Cells....Pages 135-150
Back Matter....Pages 151-153

✦ Subjects

Cell Biology; Molecular Medicine; Biochemistry, general

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