RNA Interference from Biology to Therapeutics

✍ Scribed by Jesper B. Bramsen, Thomas B. Hansen (auth.), Kenneth A. Howard (eds.)

Publisher: Springer US
Year: 2013
Tongue: English
Leaves: 347
Series: Advances in Delivery Science and Technology
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

✦ Table of Contents

Front Matter....Pages i-xv
RNA Interference Pathways and Therapeutic Exploitation....Pages 1-29
Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference....Pages 31-56
The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine....Pages 57-78
Intracellular Delivery Considerations for RNAi Therapeutics....Pages 79-95
Mucosal Delivery of RNAi Therapeutics....Pages 97-125
Nanomedicines for Systemic Delivery of RNAi Therapeutics....Pages 127-142
Lipidoids: A Combinatorial Approach to siRNA Delivery....Pages 143-160
Polymeric Micelles for siRNA Delivery....Pages 161-184
RNAi Therapeutic Delivery by Exosomes....Pages 185-205
Aptamer-Mediated siRNA Targeting....Pages 207-220
RNAi as Antiviral Therapy: The HIV-1 Case....Pages 221-242
Genome-Wide RNAi Screening to Identify Human Host Factors Crucial for Influenza Virus Replication....Pages 243-257
The Application of MicroRNAs in Cancer Diagnostics....Pages 259-298
Therapeutic Application of MicroRNAs in Cancer....Pages 299-314
Preclinical and Clinical Studies Employing RNA Interference as a Therapeutic for Respiratory Syncytial Virus (RSV) Infection in the Lung....Pages 315-328
Back Matter....Pages 329-337

✦ Subjects

Biomedicine general; Pharmaceutical Sciences/Technology

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