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RNA interference and HIV-1 infection

✍ Scribed by Luis Isamu Barros Kanzaki; Socrates Souza Ornelas; Enrique R. Argañaraz

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
374 KB
Volume
18
Category
Article
ISSN
1052-9276

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✦ Synopsis

Abstract

Life‐prolonging antiretroviral therapy remarkably reduces viral load, but it does not eradicate the virus. An important obstacle preventing virus clearance is the presence of latent virion reservoirs in the host. However, new promising antiviral approaches are emerging, and a number of host cell factors involved in the disease progression and control of HIV‐1 replication have been recently discovered. For instance, the RNA interference (RNAi) mechanism, besides many functions conserved throughout evolution, works as a defence mechanism against noxious transcripts which may provide a new tool to block viral replication. The recent definition of basic RNAi mechanisms, as well as the discovery of micro RNAs (microRNAs) encoded by the host cell genome and by HIV‐1, also suggest that RNAi may be involved in the control of HIV replication. Copyright © 2007 John Wiley & Sons, Ltd.

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