𝔖 Bobbio Scriptorium
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Viral interference in HIV-1 infected cells

✍ Scribed by Mary Jane Potash; David J. Volsky

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
268 KB
Volume
8
Category
Article
ISSN
1052-9276

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✦ Synopsis

The study of viral interference in HIV-1 infected cells has revealed several different means whereby infected cells resist superinfection. The most familiar of these, down-modulation of cellular receptors for virus, can be accomplished through the independent action of at least three HIV-1 proteins. Both the principal viral receptor CD4 and the chemokine receptors which serve as co-receptors are subject to down-modulation as a consequence of infection. Elucidation of the specificity of co-receptor utilisation by HIV-1 strains is an exciting, ongoing task which has opened new avenues to the understanding of viral replication and pathogenesis. Novel routes to resistance to superinfection have been discovered during HIV-1 infection and their investigation may reveal new pathways to control HIV-1 and the loss of immunological function with AIDS. 1998 John Wiley & Sons, Ltd.

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