Rituximab for chronic recurring thrombotic thrombocytopenic purpura: a case report and review of the literature
β Scribed by Roslyn Yomtovian; Waldemar Niklinski; Bernard Silver; Ravindra Sarode; Han-Mou Tsai
- Book ID
- 108672525
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 403 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0007-1048
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## Abstract Thrombotic thrombocytopenic purpura (TTP) is a severe lifeβthreatening hematological disorder affecting the microcirculation of multiple organ systems. Infection, pregnancy, cancer, drugs, and surgery are frequently associated with the initial episodes and relapses. Women who are either
Three patients (one with idiopathic thrombocytopenic purpura [ITP] and two with thrombotic thrombocytopenic purpura [TTP]) were treated with rituximab (anti-CD20 chimeric antibody) at a dose of 325 mg/m 2 administered weekly after they failed standard therapies. The patient with ITP who did not resp