Epidemiological studies have suggested that ataxia-telangiectasia (AT) heterozygotes have a predisposition to cancer, especially breast cancer in women. Now, haplotyping can identify heterozygotes for AT mutation (ATM) in AT families, allowing the risk of cancer associated with ATM heterozygosity st
✦ LIBER ✦
Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia
✍ Scribed by Inskip, H M; Kinlen, L J; Taylor, A MR; Woods, C G; Arlett, C F
- Book ID
- 110001071
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 70 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Ataxia‐telangiectasia (AT) is a rare autosomal recessive disorder, characterized by progressive neuronal degeneration, immunological deficiency, radio‐sensitivity and an increased risk of cancer. Although several studies have confirmed that AT heterozygosis increases the risk of breast
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