✦ LIBER ✦

Risk modifiers in carriers of brca1 mutations

✍ Scribed by Steven A. Narod; David Goldgar; Lisa Cannon-Albright; Barbara Weber; Roxanna Moslehi; Elizabeth Ives; Gilbert Lenoir; Henry Lynch

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 568 KB
Volume: 64
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910640608

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The majority of, but not all, women with mutations in the BRCAI gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCAI mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCAI carriers was found to increase significantly with increasing parity. © 1995 Wiley‐Liss, Inc.

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