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Risk factors for worsening to diabetes in subjects with impaired glucose tolerance

✍ Scribed by T. Kadowaki; Y. Miyake; R. Hagura; Y. Akanuma; H. Kajinuma; N. Kuzuya; F. Takaku; K. Kosaka

Publisher: Springer
Year: 1984
Tongue: English
Weight: 656 KB
Volume: 26
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00252262

No coin nor oath required. For personal study only.

✦ Synopsis

In a 5-12 year follow-up study of 288 subjects with impaired glucose tolerance after a 100-g glucose load, 48 worsened to overt Type 2 (non-insulin-dependent) diabetes with the elevation of fasting blood glucose. The initial level of blood glucose was a major predictor of subsequent worsening to diabetes. In addition, subjects with a lower insulin response to glucose showed a higher incidence of worsening to the disease, irrespective of blood glucose levels. Multivariate analysis indicated that a diminished insulin response and a high maximal body weight index, as well as a high level of fasting and 2-h glucose values at the initial 100-g oral glucose tolerance test were significant independent risk factors for the development of diabetes in Japanese subjects.

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