Ringerweiterung durch Fragmentierung. Synthese von 15-Pentadecanolid (Exaltolid®)
✍ Scribed by Branimir Milenkov; Armin Guggisberg; Manfred Hesse
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- German
- Weight
- 387 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Gast des Organisch-chemischen Institutes, Bulgarische Akademie der Wissenschaften, Sofia; Teil der geplanten Dissertation van B. M .
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Synthesis of Tetradecano‐14‐lactone by Ring Enlargement The aldehyde 3, prepared by ozonolysis of 2‐allyl‐2‐nitrocyclododecanone, gave the ring‐enlargement product 5(85%) by treatment with (i‐Bu)~2~AlH. Its transformation to the tetradecano‐14‐lactone (8) __via__ the aldol ester 6 and other routes
Synthesis of Macrocyles by Ring Enlargement of 14‐Membered Cyclic Imides In the presence of a base, cyclododecanone derivative 2, activated in α‐position by an allyloxycarbonyl group, underwent ring enlargement with isocyanates to give 14‐membered imides (__Schemes 1–3__). Cleavage of the activatin