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Ring Opening of 3-Bromo-2-isoxazolines to β-Hydroxy Nitriles.

✍ Scribed by Martin G. Kociolek; Kyle P. Kalbarczyk

Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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Enantioselective Ring Opening of Epoxide
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Enantioselective Ring Opening of Epoxide
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## Abstract Halohydrin dehalogenases (HheA, HheB and HheC) were found to efficiently catalyse a carbon‐carbon bond forming reaction between terminal aliphatic epoxides and cyanide, yielding β‐hydroxy nitriles. With all three enzymes nucleophilic ring opening of epoxides proceeds with high regiosele