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Enantioselective Ring Opening of Epoxides with Cyanide Catalyzed by Halohydrin Dehalogenases: A New Approach to Non-Racemic β-Hydroxy Nitriles.

✍ Scribed by Maja Majeric Elenkov; Bernhard Hauer; Dick B. Janssen

Publisher
John Wiley and Sons
Year
2006
Weight
30 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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📜 SIMILAR VOLUMES

Enantioselective Ring Opening of Epoxide
Enantioselective Ring Opening of Epoxides with Cyanide Catalysed by Halohydrin Dehalogenases: A New Approach to Non-Racemic β-Hydroxy Nitriles
✍ Maja Majerić Elenkov; Bernhard Hauer; Dick B. Janssen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract Halohydrin dehalogenases (HheA, HheB and HheC) were found to efficiently catalyse a carbon‐carbon bond forming reaction between terminal aliphatic epoxides and cyanide, yielding β‐hydroxy nitriles. With all three enzymes nucleophilic ring opening of epoxides proceeds with high regiosele