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Ring-Opening of 1-CF3-Substituted Epoxy Ethers with Carboxylic, Thiocarboxylic, and Phosphinic Acids in Basic Medium and in Hexafluoro-2-propanol

✍ Scribed by Jernej Iskra; Danièle Bonnet-Delpon; Jean-Pierre Bégué


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
202 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis


Ring-opening of 1-CF 3 -substituted epoxy ethers with carboxylic acids was achieved in Et 3 N as solvent, and α-CF 3 -substituted acyloins and corresponding esters were obtained in good yields. In hexafluoro-2-propanol (HFIP) as solvent, the carboxylic acids acted as nucleophiles, and α-carbonyloxy trifluoromethyl ketones were isolated in good yields. After reduction, CF 3 -substituted glycols were obtained as monoes- [a] BIOCIS UPRES-A


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