Comparative Study of the Ring Opening of 1-CF3-Epoxy Ethers Mediated by Broensted Acids and Hexafluoro-2-propanol.

Ring-Opening of 1-CF3-Substituted Epoxy

Ring-Opening of 1-CF3-Substituted Epoxy Ethers with Carboxylic, Thiocarboxylic, and Phosphinic Acids in Basic Medium and in Hexafluoro-2-propanol

✍ Jernej Iskra; Danièle Bonnet-Delpon; Jean-Pierre Bégué 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 1 views

Ring-opening of 1-CF 3 -substituted epoxy ethers with carboxylic acids was achieved in Et 3 N as solvent, and α-CF 3 -substituted acyloins and corresponding esters were obtained in good yields. In hexafluoro-2-propanol (HFIP) as solvent, the carboxylic acids acted as nucleophiles, and α-carbonyloxy