Ring enlargement reaction of 3-hydroxy-3-propargylisoindolin-1-ones: A new synthetic method for the 2-benzazepine-1,5-diones
β Scribed by Yoshimitsu Nagao; Ill-Yun Jeong; Woo Song Lee
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 195 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
\(N\) - \(t\)-Butylbenzamidines 1 reacted with diphenyl phenylmalonate or diphenyl methylmalonate to give 6-hydroxypyrimidin-4(3H)-ones 4 or 5 . Amidines 1 on reaction with diphenyl imidodicarboxylate afforded \(1,3,5\)-triazine- \(2,4(1 H, 3 H)\)-diones 8 .
## Abstract magnified image __N__β__t__βButylamidines **1** on heating with diphenyl carbonate (**2**) at 150β180Β° gave the 1,3,5βtriazineβ2,4(1__H__,3__H__)βdione derivatives **5**. Acylation of amidines **1** and cyclocondensation of the resulting carbamates **3** gave [1,3,5,7]tetrazocineβ2,6βd
Retro-Ene Reactions in Heterocyclic Synthesis. Part 4. A New Synthetic Method for 6-Hydroxypyrimidin-4(3H)-ones and 1,3,5-Triazine-2,4(1H,3H)-diones. -Reaction of benzamidines (I) with substituted malonates (II) and imidodicarboxylate (IV) provides an efficient access to 6-hydroxypyrimidinones (III