Ring Contracting Rearrangements of 3-Amino-4-(arylamino)-1H-isochromen-1-ones
✍ Scribed by Till Opatz; Dorota Ferenc
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 120 KB
- Volume
- 2006
- Category
- Article
- ISSN
- 1434-193X
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## Abstract Substituted 2‐(benzylamino)‐2__H__‐1,4‐benzoxazin‐3(4__H__)‐ones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2‐Bromo‐2__H__‐1,4‐benzoxazin‐3(4__H__)‐ones show similar degradation under alkaline conditions, while replacement of Br at C
## Abstract magnified image A simple one‐step method for preparation of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1__H__)‐ones has been developed by reaction of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones in refluxing toluene in the presence of KHSO~4~ and HCl.