Ring-closure reactions. 8. Synthesis and ultraviolet spectra of macrocyclic aromatic ethers
β Scribed by Mandolini, Luigi; Masci, Bernardo
- Book ID
- 121235304
- Publisher
- American Chemical Society
- Year
- 1977
- Tongue
- English
- Weight
- 498 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-3263
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Macrocyclic Polyamine Lactam Synthesis by Diphenyl Ether Closure of 23-, 24-and 28-Membered Rings. -The first synthesis of 23-, 24-, and 28-membered ring polyamine lactam conjugates (IV), (VII), and (VIII), which are nitro-substituted analogues of cadabicine class alkaloids, proceeds via the proced
## Abstract A new strategy for the synthesis of muscone **(1)** using the OHβassisted __Prins__ reaction for macrocyclic ring closure has been developed. The monoacetal **4** of (__Z__,__E__)β4,8βdodecadienedial **(3)**, easily obtainable from (__Z__,__E__,__E__)β1,5,9βcyclododecatriene **(2)**, is