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Ring-Closing Metathesis of Chiral Allylamines. Enantioselective Synthesis of (2S,3R,4S)-3,4-Dihydroxyproline.

✍ Scribed by Ruben Martin; Montserrat Alcon; Miquel A. Pericas; Antoni Riera


Publisher
John Wiley and Sons
Year
2003
Weight
261 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis and Ξ±-Mannosidase Inhibitory E
✍ Florence Popowycz; Sandrine Gerber-Lemaire; Eliazar Rodriguez-GarcΓ­a; Catherine πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 485 KB πŸ‘ 1 views

The synthesis of 46 derivatives of (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol is reported (Scheme 1 and Fig. 3), and their inhibitory activities toward a-mannosidases from jack bean (B) and almonds (A) are evaluated (Table ). The most-potent inhibitors are (2R,3R,4S)-2-{[([1,1'-biphenyl]-4-ylmet