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Ring and side chain formylated pyrazoles from acetophenone azines and Vilsmeier's reagent

✍ Scribed by Ramaiyan Manikannan; Shanmugam Muthusubramanian


Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
162 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

Differently substituted acetophenone azines on treatment with excess phosphorous oxychloride in N,N‐dimethylformamide have found to yield three products in each case. An acceptable mechanism has been suggested for the formation of all the three products. J. Heterocyclic Chem., (2011).


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Regio and stereochemically controlled ri
✍ J.R. Schauder; A. Krief 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 255 KB

This epoxide was obtained stereoselectively (> 95% ) on reaction of corresponding C-2O,C-22 olefin with osmium tetroxide (1.2 eq., 10°,1hr,85X yield) followed by basic cyclisation of the resulting C-2O,C-22 diol via its C-22 monomesylate (74% overall yield).