✦ LIBER ✦
Regio and stereochemically controlled ring opening of epoxides with grignard reagents. Stereocontrolled synthesis of the steroid side chains. first stereoselective hemisynthesis of 20s isolanosterol.
✍ Scribed by J.R. Schauder; A. Krief
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 255 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
This epoxide was obtained stereoselectively (> 95% ) on reaction of corresponding C-2O,C-22 olefin with osmium tetroxide (1.2 eq., 10°,1hr,85X yield) followed by basic cyclisation of the resulting C-2O,C-22 diol via its C-22 monomesylate (74% overall yield).