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Riluzole neuroprotection in a parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation

✍ Scribed by Marica Carbone, Susan Duty, Marcus Rattray


Book ID
119895582
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
395 KB
Volume
13
Category
Article
ISSN
1471-2202

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN