Rifampicin inhibits protein synthesis in toluene-treated Escherichia coli
β Scribed by Baharuddin A. Ghani; Peter H. Calcott
- Book ID
- 109311742
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 234 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0378-1097
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Bleomycin (BLM) is an antitumor drug which interacts with and damages DNA. We have reported a repair response dependent on DNA polymerase I in toluene-treated Escherichia coli. We report here that DNA polymerase III can also catalyze a repair response in toluene-treated E. coli following exposure to
In a rifS/rifR heterodiploid strain of E. coli, a 4 minute pulse of rifampicin can induce a prolonged (greater than 60 min) increase in the rate of synthesis of the RNA polymerase subunits, beta and beta'. The application of a constraint on the fidelity of protein synthesis during, but not after, th