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Rifampicin-induced protein synthesis: A pre-requisite for increased expression of the ??? operon in Escherichia coli

✍ Scribed by Tittawella, Ivor P. B.

Publisher: Springer
Year: 1976
Tongue: English
Weight: 423 KB
Volume: 146
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00267985

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✦ Synopsis

In a rifS/rifR heterodiploid strain of E. coli, a 4 minute pulse of rifampicin can induce a prolonged (greater than 60 min) increase in the rate of synthesis of the RNA polymerase subunits, beta and beta'. The application of a constraint on the fidelity of protein synthesis during, but not after, the rifampicin pulse partially arrests the development of this capacity for subunit synthesis. I discuss the implications of these findings in relation to the control of the BB' operon in E. coli.

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