Richter's syndrome with two different B-cell clones
β Scribed by Jan M. McDonnell; William E. Beschorner; Stephen P. Staal; Jerry L. Spivak; Risa B. Mann
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 731 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0008-543X
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A patient with two populations of B cell malignancy In the bone marrow Is reported. One population consisted of mature small lymphocytes, expressing surface IgM + D, A and proliferating very slowly. The other population consisted of abnormal large lymphoid cells, expressing surface IgM, K and prolif
## Abstract Richter's syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma and is mostly represented by diffuse large Bβcell lymphoma (DLBCL), with a postβgerminal centre (GC) phenotype, clonally related to the preβexisting CLL. RS has a very poo