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Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa

โœ Scribed by Lewin, Alfred; Drenser, Kimberly; Hauswirth, William; Nishikawa, Shimpei; Yasumura, Douglas; Flannery, John; LaVail, Matthew

Book ID
109645403
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
36 KB
Volume
4
Category
Article
ISSN
1078-8956

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Transgenic mice expressing a dominant mutation in the gene for the phototransduction molecule rhodopsin undergo retinal degeneration similar to that experienced by patients with the retinal degenerative disease, retinitis pigmentosa (RP). Although the mutation is thought to cause photoreceptor degen