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RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor

✍ Scribed by Claire Médale-Giamarchi, Isabelle Lajoie-Mazenc, Emilie Malissein…

Book ID
120699073
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
734 KB
Volume
15
Category
Article
ISSN
1465-5411

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Estrogen regulated expression of the p21
Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells
✍ Soma Mandal; James R. Davie 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept