RhoA: A therapeutic target for chronic myeloid leukemia
โ Scribed by Poonam R Molli, Madhura B Pradhan, Suresh H Advani, Nishigandha R Naik
- Book ID
- 119901822
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 844 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1476-4598
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## Abstract Chronic myeloid leukaemia (CML) is a clonal disorder of the haemopoietic stem cell arising as a consequence of the formation of the __bcrโabl__ oncogene. The particular molecular basis of this condition has enabled the development of therapies that selectively target diseased cells. The
Various clinical observations have implicated T cells in the control of chronic myeloid leukemia (CML). These observations have in recent years been supported by laboratory results indicating the presence of CML-specific T cells in the lymphocyte repertoire of both normal healthy individuals and dis