Rho GTPases: Masters of T lymphocyte migration and activation
✍ Scribed by Pablo Rougerie; Jérôme Delon
- Book ID
- 116569750
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 681 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0165-2478
No coin nor oath required. For personal study only.
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The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. The
Infiltration of monocytes and macrophages into the site of inflammation is critical in the progression of inflammatory diseases such as atherosclerosis. Cell migration is dependent on the continuous organization of the actin cytoskeleton, which is regulated by members of the small Rho GTPase family