Redistribution of Bruton's tyrosine kina
β
Beston F. Nore; Leonardo Vargas; Abdalla J. Mohamed; Lars J. BrandΓ©n; Carl-Magnu
π
Article
π
2000
π
John Wiley and Sons
π
English
β 504 KB
Bruton's tyrosine kinase (Btk) is a member of the Tec family of protein tyrosine kinases (PTK) characterized by an N-terminal pleckstrin homology domain (PH) thought to directly interact with phosphoinositides. We report here that wild-type (wt) and also a gain-of-function mutant of Btk are redistri