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Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

✍ Scribed by Paul Timpson; Gareth E. Jones; Margaret C. Frame; Valerie G. Brunton


Book ID
114318674
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
486 KB
Volume
11
Category
Article
ISSN
0960-9822

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Redistribution of Bruton's tyrosine kina
✍ Beston F. Nore; Leonardo Vargas; Abdalla J. Mohamed; Lars J. BrandΓ©n; Carl-Magnu πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 504 KB

Bruton's tyrosine kinase (Btk) is a member of the Tec family of protein tyrosine kinases (PTK) characterized by an N-terminal pleckstrin homology domain (PH) thought to directly interact with phosphoinositides. We report here that wild-type (wt) and also a gain-of-function mutant of Btk are redistri