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Rheumatoid synovial cell hormone responses modulated by cell-cell interactions

✍ Scribed by S. R. Goldring; J. -M. Dayer; S. M. Krane


Publisher
Springer
Year
1984
Tongue
English
Weight
956 KB
Volume
8
Category
Article
ISSN
0360-3997

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Adherent rheumatoid synovial cells in culture produce large amounts of prostaglandin E2 (PGE2) and collagenase. When exposed to a monocyte-derived factor, such cells exhibit marked increases in PGE2 and collagenase production. In addition, cellular morphology becomes more stellate. In the presence o