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Influence of rheumatoid synovial fluid and cells on proteoglycans in human cartilage explants. Modulation by piroxicam

✍ Scribed by B. Wilbrink; J. Vernooy; W. Otter; J. L. A. M. Roy; J. Huber; O. Huber-Bruning


Publisher
Springer
Year
1992
Tongue
English
Weight
465 KB
Volume
11
Category
Article
ISSN
0770-3198

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Objective. To examine whether T cell reactivity toward heat-shock proteins (HSP) contributes to cartilage destruction in rheumatoid arthritis (RA). Methods. An in vitro system was used, in which human cartilage explants were cocultured with hsp60activated synovial fluid mononuclear cells (SFMC) fro