Rheumatoid arthritis therapy after tumor necrosis factor and interleukin-1 blockade
✍ Scribed by Kurt Redlich; Georg Schett; Günter Steiner; Silvia Hayer; Erwin F. Wagner; Josef S. Smolen
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 711 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
With concomitant methotrexate. † Pegylated recombinant methionyl human soluble tumor necrosis factor type I.
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## Abstract ## Objective Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF)–blocking agents, including etanercept and infliximab, has resulted in reductions in the radiographic progression of RA. However, the exact mechanism by which this protection occurs has not been determi
## Objective: To investigate the regulation of expression of the angiogenic cytokine vascular endothelial growth factor (vegf) in rheumatoid arthritis (ra), in order to determine whether new blood vessel formation could be a potential therapeutic target in ra. ## Methods: Dissociated ra synovial