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RGD–cyclam conjugate: Synthesis and potential application for positron emission tomography

✍ Scribed by Mathieu Galibert; Zhao-Hui Jin; Takako Furukawa; Toshimitsu Fukumura; Tsuneo Saga; Yasuhisa Fujibayashi; Pascal Dumy; Didier Boturyn

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 580 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.07.114

No coin nor oath required. For personal study only.

✦ Synopsis

Cyclam and DOTA-containing positron emission tomography radiotracers were prepared by using a modular chemical strategy based on peptide synthesis and chemoselective ligations. These molecules encompass two functional domains, one a tumour 'homing' domain and the other a chelating ligand for copper allowing nuclear imaging of tumours.

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## Abstract For Abstract see ChemInform Abstract in Full Text.