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Review of the putative association of dopamine D2 receptor and alcoholism: A meta-analysis

✍ Scribed by Pato, Carlos N. ;Macciardi, Fabio ;Pato, Michele T. ;Verga, Massimiliano ;Kennedy, James L.


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
485 KB
Volume
48
Category
Article
ISSN
0148-7299

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Dopaminergic systems mediate reward mechanisms and are involved in reinforcing self-administration of dependence-forming substances, including alcohol. Studies have reported that polymorphisms of the dopamine D2 receptor, whose structure and function are similar to those of the dopamine D3 receptor,

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A recent study showed an association between the dopamine D2 receptor gene (DRD2) and smoking. The purpose of this study was to determine if the familial transmission of smoking is linked to variation at the DRD2 locus in a genetically informative sample. Subjects were identified in alcohol treatmen

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Association studies between the A1 allele of the dopamine D2 receptor (DRDS) gene TuqI A polymorphism and alcoholism remain controversial. A recent study from Japan demonstrated that the A1 allele is associated with severe alcoholism in the Japanese population. We were interested in knowing if this