Review of epidermal growth factor receptor biology
β Scribed by Roy S Herbst
- Book ID
- 108148323
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 169 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0360-3016
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-g
The association/dissociation binding kinetics of 1251-labeled mouse epidermal growth factor (EGF) to receptors on human fibroblast cells in monolayer culture have been measured at 4Β°C as a function of extracellular pH from pH 5-9. At pH 8, steady-state total binding is maximal. As pH is lowered to 6